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In different studies, apoptosis has been considered to be one of the mechanisms involved in D-galactose-induced neurotoxicity and hepatotoxicity [5, 36]

S., Ho, W

doi: 10.1007/BF02867412

High homocysteine levels are problematic because they have been linked to heart disease and atherosclerosis.32 In people who are deficient or have mutations in the enzymes that catalyze the production of glutathione from homocysteine, the methylation cycle will be under pressure to remove excess homocysteine

Furthermore, recent studies in both laboratory animals and humans increasingly sug-gest that moderate hyperhomocysteinemia impairs endothelial-dependent vasodilation (Bellamy et al, 1999

These parameters can be interpreted as the second order rate constant for the oxidative half-reaction with GSSCys, yielding glutathionylated enzyme and cysteine, and the reductive half-reaction with GSH, yielding reduced enzyme and glutathione disulfide (GSSG) 12,39 (Fig